SEARCH

SEARCH BY CITATION

Keywords:

  • atropisomerism;
  • chiral resolution;
  • mechanochemistry;
  • polymers;
  • ultrasound
Thumbnail image of graphical abstract

Good combination: Enantioselective enzymatic hydrolysis was combined with a mechanically facilitated racemization process to prepare (S)-1,1′-binapthol ((S)-binol) in high yield and enantiopurity from a racemic precursor in a single step (see scheme). The enzyme cholesterol esterase stereoselectively hydrolyzes esters of (S)-binol and ultrasound was applied to achieve mechanically facilitated racemization of the precursor material.