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A Mechanochemical Approach to Deracemization

Authors

Errata

This article is corrected by:

  1. Errata: Retraction: A Mechanochemical Approach to Deracemization Volume 54, Issue 3, 720, Article first published online: 8 January 2015

  • We are grateful to the ARO (W911NF-07-10409) and the Welch Foundation (F-1621) for their generous financial support. We also thank Prof. A. T. Keating-Clay and A. J. Hughes for helpful discussions.

Abstract

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Good combination: Enantioselective enzymatic hydrolysis was combined with a mechanically facilitated racemization process to prepare (S)-1,1′-binapthol ((S)-binol) in high yield and enantiopurity from a racemic precursor in a single step (see scheme). The enzyme cholesterol esterase stereoselectively hydrolyzes esters of (S)-binol and ultrasound was applied to achieve mechanically facilitated racemization of the precursor material.

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