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Stimulated Release of Size-Selected Cargos in Succession from Mesoporous Silica Nanoparticles

Authors

  • Dr. Cheng Wang,

    1. Center for the Chemistry of Integrated Systems, Department of Chemistry and Department of Material Sciences, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)
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    • These authors contributed equally to this work.

  • Zongxi Li,

    1. Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095 (USA)
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    • These authors contributed equally to this work.

  • Dennis Cao,

    1. Center for the Chemistry of Integrated Systems, Department of Chemistry and Department of Material Sciences, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)
    2. NanoCentury KAIST Institute and Graduate School of EEWS (WCU), Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong Dong, Yuseong Gu, Daejeon 305-701 (Republic of Korea)
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  • Dr. Yan-Li Zhao,

    1. Center for the Chemistry of Integrated Systems, Department of Chemistry and Department of Material Sciences, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)
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  • Justin W. Gaines,

    1. Center for the Chemistry of Integrated Systems, Department of Chemistry and Department of Material Sciences, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)
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  • Dr. O. Altan Bozdemir,

    1. Center for the Chemistry of Integrated Systems, Department of Chemistry and Department of Material Sciences, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)
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  • Michael W. Ambrogio,

    1. Center for the Chemistry of Integrated Systems, Department of Chemistry and Department of Material Sciences, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)
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  • Dr. Marco Frasconi,

    1. Center for the Chemistry of Integrated Systems, Department of Chemistry and Department of Material Sciences, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)
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  • Dr. Youssry Y. Botros,

    1. Center for the Chemistry of Integrated Systems, Department of Chemistry and Department of Material Sciences, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)
    2. Intel Labs, Building RNB-6-61, 2200 Mission College Blvd., Santa Clara, CA 95054 (USA)
    3. National Center for Nano Technology Research, King Abdulaziz City for Science and Technology (KACST), P.O. BOX 6086, Riyadh 11442 (Kingdom of Saudi Arabia)
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  • Prof. Jeffrey I. Zink,

    Corresponding author
    1. Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095 (USA)
    • Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095 (USA)
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  • Prof. J. Fraser Stoddart

    Corresponding author
    1. Center for the Chemistry of Integrated Systems, Department of Chemistry and Department of Material Sciences, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)
    2. NanoCentury KAIST Institute and Graduate School of EEWS (WCU), Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong Dong, Yuseong Gu, Daejeon 305-701 (Republic of Korea)
    • Center for the Chemistry of Integrated Systems, Department of Chemistry and Department of Material Sciences, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)
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  • The research at Northwestern University (NU) was enabled by the National Center for Nano Technology Research at the King Abdulaziz City for Science and Technology (KACST) in Saudi Arabia. The authors thank Dr. Turki S. Al-Saud and Dr. Mohamed B. Alfageeh at KACST for their generous support of this research. We also acknowledge support from the World Class University (WCU) Program (R-31-2008-000-10055-0) in Korea. The research at the University of California, Los Angeles (UCLA), was supported by the U.S. National Science Foundation under Grant CHE-0809384 and by the U.S. Department of Defense under Grant HDTRA1-08-1-0041. D.C. thanks the National Science Foundation for a Graduate Research Fellowship. We thank Aleksandr Bosoy for generating images for incorporation into the illustrations.

Abstract

original image

Two birds with one stone: Covalent attachment of β-cyclodextrin rings (yellow; see figure) to mesoporous silica nanoparticles (MSNs) results in a dual-cargo release system into which differently sized cargos (blue and red spheres) can be loaded and then released in sequence when triggered by two different stimuli. The smaller molecules are released by lowering the pH value and the larger ones released after cleavage of the cyclodextrins from the MSN surface.

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