Two birds with one stone: Covalent attachment of β-cyclodextrin rings (yellow; see figure) to mesoporous silica nanoparticles (MSNs) results in a dual-cargo release system into which differently sized cargos (blue and red spheres) can be loaded and then released in sequence when triggered by two different stimuli. The smaller molecules are released by lowering the pH value and the larger ones released after cleavage of the cyclodextrins from the MSN surface.
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