Naked-eye detection: The versatility of direct-write nanolithography was combined with the unrivaled resolution and selectivity of molecular self-assembly to show, for the first time, the molecularly mediated placement, with nanometer accuracy, of single Au nanoparticles within a plasmonic array. In doing so, a coupled plasmonic systems was created which allowed colorimetric, naked-eye detection of protein–protein binding at extreme sensitivities.
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