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Unlocking the 1,2,3-Triazole Ring Using Mechanical Force

Authors

  • Dr. Yuan Lin,

    1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (P. R. China)
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  • Prof. Qian Wang

    Corresponding author
    1. Department of Chemistry & Biochemistry, University of South Carolina, Columbia, SC 29208 (USA)
    • Department of Chemistry & Biochemistry, University of South Carolina, Columbia, SC 29208 (USA)
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  • Q.W. is grateful to a guest professorship from CIAC and the Robert L. Sumwalt Prof. endowment at USC. Y.L. gratefully acknowledges the financial support from the State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, the Chinese Academy of Sciences, and the National Natural Science Foundation of China (Programs 21128002 and 21104080).

Abstract

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K(l)ick it into reverse: Mechanical force (ultrasound) may be employed to promote a retrocycloaddition reaction of a 1,2,3-triazole to regenerate the parent azide and alkyne, a reaction that cannot be achieved by other means.

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