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Reversible ON/OFF Nanoswitch for Organocatalysis: Mimicking the Locking and Unlocking Operation of CaMKII


  • We are grateful to the Deutsche Forschungsgemeinschaft and the Universität Siegen for financial support. CaMKII=calcium/calmodulin-dependent protein kinase II.


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Flip a switch: A nanoswitch uses chemical inputs to turn an organocatalytic Knoevenagel reaction on and off (see scheme: R=reactant, P=product). To stop catalysis the chemical input (pink and green) wraps around the inhibitory segment of the nanoswitch to effect release or unlocking of the switch. The process can run reversibly over three cycles without loss of activity.

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