We thank the National Institutes of Health (GM46059) for financial support of this project. The Varian 400 MHz NMR spectrometer used in this work was supported by grants from the National Institutes of Health (1S10RR13886-01). We thank the National Science Foundation for departmental X-ray diffraction instrumentation (CHE-0946721).
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Communication
Combined Oxypalladation/C![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
H Functionalization: Palladium(II)-Catalyzed Intramolecular Oxidative Oxyarylation of Hydroxyalkenes†
Article first published online: 11 JAN 2012
DOI: 10.1002/anie.201108129
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Zhu, R. and Buchwald, S. L. (2012), Combined Oxypalladation/CH Functionalization: Palladium(II)-Catalyzed Intramolecular Oxidative Oxyarylation of Hydroxyalkenes. Angew. Chem. Int. Ed., 51: 1926–1929. doi: 10.1002/anie.201108129
- †
Publication History
- Issue published online: 14 FEB 2012
- Article first published online: 11 JAN 2012
- Manuscript Received: 18 NOV 2011
Funded by
- National Institutes of Health. Grant Numbers: GM46059, 1S10RR13886-01
- National Science Foundation. Grant Number: CHE-0946721
Keywords:
- CH activation;
- heterocyclic compounds;
- homogeneous catalysis;
- palladium;
- synthetic methods
An efficient protocol has been developed for the intramolecular oxidative oxyarylation using a PdII-catalyzed tandem oxypalladation/CH functionalization strategy. This methodology allows rapid access to tetrahydro-2H-indeno-[2,1-b]furan frameworks from simple hydroxyalkenes. The reactivity of this process is orthogonal to that of Pd0-catalyzed transformations, enabling the divergent modification of a single molecule.