Cover Picture

Cover Picture: Dynamics and Multiple Stable Binding Modes of DNA Intercalators Revealed by Single-Molecule Force Spectroscopy (Angew. Chem. Int. Ed. 8/2012)

  1. Dr. D. Hern Paik,
  2. Prof. Thomas T. Perkins*

Article first published online: 8 DEC 2011

DOI: 10.1002/anie.201108162

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 8, page 1731, February 20, 2012

Additional Information

How to Cite

Paik, D. H. and Perkins, T. T. (2012), Cover Picture: Dynamics and Multiple Stable Binding Modes of DNA Intercalators Revealed by Single-Molecule Force Spectroscopy (Angew. Chem. Int. Ed. 8/2012). Angew. Chem. Int. Ed., 51: 1731. doi: 10.1002/anie.201108162

Author Information

  1. JILA, National Institute of Standards and Technology and University of Colorado, Boulder; Department of Molecular, Cellular, and Developmental Biology, University of Colorado, 440 UCB, Boulder, CO 80309-0440 (USA) http://jila.colorado.edu/perkinsgroup/

*JILA, National Institute of Standards and Technology and University of Colorado, Boulder; Department of Molecular, Cellular, and Developmental Biology, University of Colorado, 440 UCB, Boulder, CO 80309-0440 (USA) http://jila.colorado.edu/perkinsgroup/

Publication History

  1. Issue published online: 14 FEB 2012
  2. Article first published online: 8 DEC 2011

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Keywords:

  • DNA;
  • force spectroscopy;
  • intercalations;
  • optical traps;
  • single-molecule studies
Thumbnail image of graphical abstract

Intercalation of YOYO a bisintercalating DNA dye, was studied by using single-molecule force spectroscopy. In their Communication on page 1811 ff., D. H. Paik and T. T. Perkins show that force-enhanced intercalation, traditionally ascribed to the dye in solution binding to the DNA, can occur from a reservoir of bound dye that remained out of equilibrium with the free dye for long periods of time (>2 hours). Hence, binding/unbinding and intercalation/de-intercalation are distinct processes that can occur on very different time scales.

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