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Organometallic Ruthenium and Iridium Transfer-Hydrogenation Catalysts Using Coenzyme NADH as a Cofactor

Authors


  • We thank the WPRS and the ORSAS (S.B.-L. and Z.L.), and the CONACyT Mexico (S.B-L.) for research scholarships, the EPSRC, the ERC (BIOINCMED), the ERDF, and the AWM (Science City) for funding. Dr. Ivan Prokes, Dr. Lijiang Song, and Mr Philip Aston (University of Warwick) are acknowledged for assistance with the NMR and MS instruments, respectively, Prof. Colin Murrell and Dr. Andrew Crombie are thanked for assistance with the gas chromatograph, and Dr. Ying Fu and Dr. Maria Romero Castro are thanked for helpful discussions.

Abstract

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Artificial enzymes: Half-sandwich arene ruthenium(II) and cyclopentadienyl iridium(III) complexes containing N,N-chelated ligands can use NADH as a source of hydride for the reduction of ketones (see picture). Moreover, cyclopentadienyl phenanthroline iridium(III) derivatives at micromolar concentrations are robust catalysts for the production of H2 from NADH in water and can raise the NAD+/NADH ratio in cancer cells.

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