The authors thank the EPSRC and Dr. Reddy’s Laboratories for funding, and EPSRC for the use of the National Mass Spectrometry Service.
An Asymmetric Hydroformylation Catalyst that Delivers Branched Aldehydes from Alkyl Alkenes†
Article first published online: 27 JAN 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 10, pages 2477–2480, March 5, 2012
How to Cite
Noonan, G. M., Fuentes, J. A., Cobley, C. J. and Clarke, M. L. (2012), An Asymmetric Hydroformylation Catalyst that Delivers Branched Aldehydes from Alkyl Alkenes. Angew. Chem. Int. Ed., 51: 2477–2480. doi: 10.1002/anie.201108203
- Issue published online: 1 MAR 2012
- Article first published online: 27 JAN 2012
- Manuscript Received: 22 NOV 2011
- Dr. Reddy’s Laboratories
- asymmetric hydroformylation;
- phosphine-phosphite ligands;
Surprising selectivity: The first enantioselective hydroformylations of simple alkenes of type RCH2CHCH2 to preferentially deliver the branched aldehyde product have been discovered using a new chiral ligand, named bobphos (see scheme). Established ligands are unselective in this reaction or show a slight preference towards the linear aldehyde.