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An Asymmetric Hydroformylation Catalyst that Delivers Branched Aldehydes from Alkyl Alkenes

Authors

  • Dr. Gary M. Noonan,

    1. School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, KY16 9ST (UK)
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  • Dr. José A. Fuentes,

    1. School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, KY16 9ST (UK)
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  • Dr. Christopher J. Cobley,

    Corresponding author
    1. Chirotech Technology Ltd., Dr. Reddy's Laboratories (EU) Limited, 410 Cambridge Science Park, Milton Road, Cambridge, CB4 OPE (UK)
    • Chirotech Technology Ltd., Dr. Reddy's Laboratories (EU) Limited, 410 Cambridge Science Park, Milton Road, Cambridge, CB4 OPE (UK)
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  • Dr. Matthew L. Clarke

    Corresponding author
    1. School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, KY16 9ST (UK)
    • School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, KY16 9ST (UK)
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  • The authors thank the EPSRC and Dr. Reddy’s Laboratories for funding, and EPSRC for the use of the National Mass Spectrometry Service.

Abstract

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Surprising selectivity: The first enantioselective hydroformylations of simple alkenes of type RCH2CH[DOUBLE BOND]CH2 to preferentially deliver the branched aldehyde product have been discovered using a new chiral ligand, named bobphos (see scheme). Established ligands are unselective in this reaction or show a slight preference towards the linear aldehyde.

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