Total Synthesis of the Galbulimima Alkaloid (−)-GB17


  • This work was supported in part by Northwestern University (NU), Amgen, and the National Institutes of Health (1R01GM085322). We thank Prof. Lewis N. Mander (The Australian National University) for providing an authentic sample of (−)-GB17.


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A tale of two Michaels: The first enantioselective total synthesis of (−)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions, one under catalyst control and the other under substrate control.