A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?


  • We gratefully acknowledge the financial support of the Australian Research Council, the National Health and Medical Research Council, and the Research Grants Council, Hong Kong (GRF774109 and AoE/M-12/06).


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One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase).