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Keywords:

  • carbocycles;
  • cyclizations;
  • steroids;
  • sulfur heterocycles;
  • synthetic methods
Thumbnail image of graphical abstract

The fifth element: An efficient new synthetic method for accessing 3,6-dihydro-2H-thiopyrans 1 in one pot has been developed. This method employs an anionic cascade, which is triggered by the addition of a vinyl nucleophile to a carbonyl group followed by S to O thiophosphate migration and an intramolecular thiolate displacement. The scope is demonstrated for a range of ketone and ester substrates.