This work was supported by MaRS Innovation, the Canadian Cancer Society, CIHR, NSERC, and the Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research.
Enzymatic Regioselection for the Synthesis and Biodegradation of Porphysome Nanovesicles†
Article first published online: 20 JAN 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 10, pages 2429–2433, March 5, 2012
How to Cite
Lovell, J. F., Jin, C. S., Huynh, E., MacDonald, T. D., Cao, W. and Zheng, G. (2012), Enzymatic Regioselection for the Synthesis and Biodegradation of Porphysome Nanovesicles. Angew. Chem. Int. Ed., 51: 2429–2433. doi: 10.1002/anie.201108280
- Issue published online: 1 MAR 2012
- Article first published online: 20 JAN 2012
- Manuscript Revised: 15 DEC 2011
- Manuscript Received: 24 NOV 2011
- MaRS Innovation
- Canadian Cancer Society
- Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research
A select few: An enzyme screen is used to identify two enzymes that selectively cleave porphyrin–lipid regioisomers (see picture). Either of the isomerically pure conjugates assembles into physically similar porphysome nanovesicles. Although porphysomes formed from both regioisomers are stable in serum in vivo, only one regioisomer rapidly degrades upon uptake in the liver.