Communication

Photodynamic Effect in Near-IR Light by a Photocytotoxic Iron(III) Cellular Imaging Agent†

  1. Uttara Basu1,
  2. Imran Khan2,
  3. Akhtar Hussain1,
  4. Prof. Paturu Kondaiah2,*,
  5. Prof. Akhil R. Chakravarty1,*

Article first published online: 30 JAN 2012

DOI: 10.1002/anie.201108360

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 11, pages 2658–2661, March 12, 2012

Additional Information

How to Cite

Basu, U., Khan, I., Hussain, A., Kondaiah, P. and Chakravarty, A. R. (2012), Photodynamic Effect in Near-IR Light by a Photocytotoxic Iron(III) Cellular Imaging Agent. Angew. Chem. Int. Ed., 51: 2658–2661. doi: 10.1002/anie.201108360

Author Information

  1. 1

    Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, Karnataka (India)

  2. 2

    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, Karnataka (India)

*Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, Karnataka (India)

  1. †

    We thank the Department of Science and Technology (DST), Government of India, for financial support (SR/S5/MBD-02/2007) and the Alexander von Humboldt Foundation (Germany) for an electrochemical system. A.R.C. thanks DST for a J. C. Bose Fellowship. I.K and A.H. thank the Council of Scientific and Industrial Research (CSIR), New Delhi, for research fellowships. We thank Prof. Sudhakar Rao and Mr. Saravanan, Civil Engineering Department, IISc for the AAS facility.

Publication History

  1. Issue published online: 7 MAR 2012
  2. Article first published online: 30 JAN 2012
  3. Manuscript Revised: 16 JAN 2012
  4. Manuscript Received: 28 NOV 2011

Funded by

  • Department of Science and Technology (DST). Grant Number: SR/S5/MBD-02/2007
  • Alexander von Humboldt Foundation
  • DST
  • Council of Scientific and Industrial Research (CSIR)

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Keywords:

  • antitumor agents;
  • bioinorganic chemistry;
  • cancer;
  • iron;
  • photodynamic therapy
Thumbnail image of graphical abstract

A red light for cancer cells: An iron(III) complex (1, see picture) that contains an anthracenyl fluorophore moiety and a catecholate ligand is a potent, metal-based PDT agent that efficiently photocleaves DNA in near-infrared light, has significant nuclear uptake, and high photocytotoxicity in red light by an apoptotic pathway in HeLa and MCF-7 cancer cells.

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