Back Cover: Switching the Targeting Pathways of a Therapeutic Antibody by Nanodesign (Angew. Chem. Int. Ed. 7/2012)

Authors

  • Dr. Sanjib Bhattacharyya,

    1. Department of Biochemistry and Molecular Biology, Guggenheim 1311B, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (USA)
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  • Dr. Raman Deep Singh,

    1. Department of Biochemistry and Molecular Biology, Guggenheim 1311B, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (USA)
    2. Thoracic Disease Research Unit, Mayo Clinic, Rochester, MN 55905 (USA)
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  • Dr. Richard Pagano,

    1. Thoracic Disease Research Unit, Mayo Clinic, Rochester, MN 55905 (USA)
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    • Deceased

  • Dr. J. David Robertson,

    1. Department of Chemistry and University of Missouri Research Reactor, University of Missouri, Columbia, MO 65211 (USA)
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  • Dr. Resham Bhattacharya,

    1. Department of Biochemistry and Molecular Biology, Guggenheim 1311B, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (USA)
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  • Dr. Priyabrata Mukherjee

    Corresponding author
    1. Department of Biochemistry and Molecular Biology, Guggenheim 1311B, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (USA)
    2. Biomedical Engineering, Mayo Clinic, Rochester, MN 55905 (USA)
    3. Cancer Center, College of Medicine, Mayo Clinic, Rochester, MN 55905 (USA)
    • Department of Biochemistry and Molecular Biology, Guggenheim 1311B, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (USA)
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Abstract

original image

Gold nanoparticles can be used as a scaffold to elucidate the mechanism of endocytosis of cetuximab and its nanoconjugates, as well as the switching of endocytic pathways (caveolar versus pinocytotic) in pancreatic cancer cells, as demonstrated by P. Mukherjee and co-workers in their Communication on page 1563 ff. Tailoring the mechanism of endocytosis may be useful for targeting specific intracellular pathways to minimize the side effects of pharmaceutical compounds.

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