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Organogold(III) Supramolecular Polymers for Anticancer Treatment

Authors

  • Jing-Jing Zhang,

    1. State Key Laboratory of Synthetic Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
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  • Dr. Wei Lu ,

    1. State Key Laboratory of Synthetic Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
    2. Department of Chemistry, South University of Science and Technology of China, 1088 Xueyuan Boulevard, Shenzhen, Guangdong 518055 (China)
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  • Dr. Raymond Wai-Yin Sun,

    Corresponding author
    1. State Key Laboratory of Synthetic Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
    • State Key Laboratory of Synthetic Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
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  • Prof. Dr. Chi-Ming Che

    Corresponding author
    1. State Key Laboratory of Synthetic Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
    • State Key Laboratory of Synthetic Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
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  • This work is supported by The Innovation and Technology Fund (Tier-2 project, ITS/134/09FP) administrated by The Innovation and Technology Commission and The Area of Excellence Scheme (AoE/P-10/01) established under the University Grants Committee of the Hong Kong Special Administrative Region, China. We thank Dr. Xiangguo Guan for performing the molecular modeling. Thanks go to Frankie Yu-Fee Chan and Amy Sui-Ling Wong at HKU for assistance in electron microscopy.

Abstract

original image

Gold cures: The depicted gold(III) complex self-assembles into supramolecular polymers which form nanofibrillar networks that display sustained cytotoxicity and can also act as carriers for other cytotoxic agents.

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