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Total Synthesis and Structural Revision of the Piperarborenines: When Photochemistry Meets C[BOND]H Activation


  • We thank the Max-Planck Society and the Max-Planck-Institut für Kohlenforschung, the European Research Council (grant 278872), and the Deutsche Forschungsgemeinschaft (grant MA-4861/3-1) for generous support.


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Activate and reiterate: The activation of C(sp3)[BOND]H bonds is a highly desirable transformation because molecular complexity can be increased at the expense of the most simple and readily available organic linkage. In recent contributions this approach was used for coupling reactions with small all-carbon rings, as exemplified by the sequential C[BOND]H activation steps in an elegant total synthesis of the piperarborenines (see scheme; DG=directing group).