Inside Cover: A Synthetic Approach Toward a Self-Regulated Insulin Delivery System (Angew. Chem. Int. Ed. 9/2012)

Authors

  • Dr. Akira Matsumoto,

    1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062 (Japan)
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    • These authors contributed equally to this work.

  • Dr. Takehiko Ishii,

    1. Department of Bioengineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan)
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    • These authors contributed equally to this work.

  • Junko Nishida,

    1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062 (Japan)
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  • Dr. Hiroko Matsumoto,

    1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062 (Japan)
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  • Dr. Kazunori Kataoka,

    1. Department of Materials Science and Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan)
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  • Dr. Yuji Miyahara

    Corresponding author
    1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062 (Japan)
    • Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062 (Japan)
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Abstract

original image

A totally synthetic artificial pancreas is described by Y. Miyahara et al. in their Communication on page 2124 ff. A hydrogel bearing a phenylboronate derivative undergoes a glucose-dependent transition in its state of hydration under physiological conditions. The reversible surface-localized dehydration enables the provision of insulin to be controlled, thus offering a new basis for the treatment of diabetes with long-term stability and safety.

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