Formation of Single-Chain Polymer Nanoparticles in Water through Host–Guest Interactions

Authors

  • Eric A. Appel,

    1. Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW (UK)
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  • Joseph Dyson,

    1. Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW (UK)
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  • Dr. Jesús del Barrio,

    1. Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW (UK)
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  • Dr. Zarah Walsh,

    1. Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW (UK)
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  • Dr. Oren A. Scherman

    Corresponding author
    1. Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW (UK)
    • Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW (UK)
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  • E.A.A. thanks Schlumberger for financial support and J.d.B is grateful for a Marie Curie Intraeuropean Fellowship (project number 273807). This work was also supported by an ERC Starting Investigator Grant (ASPiRe) and a Next Generation Fellowship provided by the Walters-Kundert Foundation.

Abstract

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Smart materials: Metastable single-chain polymeric nanoparticles were prepared through stimuli-responsive and reversible intramolecular crosslinking of a single polymer chain in water. Functionalization of poly(N-hydroxyethylacrylamide) polymers with two complementary guests for cucurbit[8]uril (CB[8]), namely viologen and naphthalene, followed by addition of the macrocycle thus allowed for facile preparation of such nanoparticles (see picture).

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