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Keywords:

  • antifreeze proteins;
  • chemical ligation;
  • glycopeptides;
  • glycoproteins;
  • thermal hysteresis
Thumbnail image of graphical abstract

Don't freeze! A native chemical ligation–desulfurization strategy has been employed for the convergent synthesis of a library of defined antifreeze glycopeptides and glycoproteins (AFGPs) ranging in size from 1.2 to 19.5 kDa (see picture). These AFGPs possessed the secondary structure of a polyproline type II helix and exhibited significant ice recrystallization inhibition and thermal hysteresis activity.