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Keywords:

  • biomaterials;
  • monolayers;
  • peptides;
  • self-assembled monolayers;
  • stem cells
Thumbnail image of graphical abstract

Sticky situation: The differentiation of mesenchymal stem cells can be influenced by the affinity and density of an immobilized ligand for the integrin receptors. Cells adherent to monolayers that present the high-affinity, cyclic-RGD peptide (left) show increased expression of osteogenic markers, while cells on monolayers presenting the lower-affinity, linear-RGD peptide (right) express early markers of myogenesis at a high density and neurogenesis at a low density of the ligand.