This work was supported by the National Cancer Institute of the National Institutes of Health. K.A.K. was supported by a Ruth L. Kirschstein National Research Service Award Number F32M087048 from the National Institute of General Medical Sciences of the National Institutes of Health.
Directing Stem Cell Fate by Controlling the Affinity and Density of Ligand–Receptor Interactions at the Biomaterials Interface†
Article first published online: 13 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 20, pages 4891–4895, May 14, 2012
How to Cite
Kilian, K. A. and Mrksich, M. (2012), Directing Stem Cell Fate by Controlling the Affinity and Density of Ligand–Receptor Interactions at the Biomaterials Interface. Angew. Chem. Int. Ed., 51: 4891–4895. doi: 10.1002/anie.201108746
- Issue published online: 8 MAY 2012
- Article first published online: 13 APR 2012
- Manuscript Received: 12 DEC 2011
- National Institutes of Health
- self-assembled monolayers;
- stem cells
Sticky situation: The differentiation of mesenchymal stem cells can be influenced by the affinity and density of an immobilized ligand for the integrin receptors. Cells adherent to monolayers that present the high-affinity, cyclic-RGD peptide (left) show increased expression of osteogenic markers, while cells on monolayers presenting the lower-affinity, linear-RGD peptide (right) express early markers of myogenesis at a high density and neurogenesis at a low density of the ligand.