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Keywords:

  • axon outgrowth;
  • cytoskeletal proteins;
  • nanostructures;
  • neurochemistry;
  • silica bead
Thumbnail image of graphical abstract

Topographical cues play an important role in in vitro neuronal development. In their Communication on page 2855 ff., Y. Nam, I. S. Choi, J. S. Lee, and co-workers show that neuritogenetic acceleration occurs on silica-bead monolayers made up of beads with a diameter of more than 200 nm, but not on monolayers of beads with smaller diameters. The biochemical study indicates neurons sense topographical differences in nanostructures and alter their behavior accordingly.