Topographical cues play an important role in in vitro neuronal development. In their Communication on page 2855 ff., Y. Nam, I. S. Choi, J. S. Lee, and co-workers show that neuritogenetic acceleration occurs on silica-bead monolayers made up of beads with a diameter of more than 200 nm, but not on monolayers of beads with smaller diameters. The biochemical study indicates neurons sense topographical differences in nanostructures and alter their behavior accordingly.
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