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The Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes


  • This work was supported by the German Research Foundation (DFG) and the U.S. National Institutes of Health (CA114046). S.B. acknowledges a stipend from the Fonds der Chemischen Industrie.


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Better fit, less effort: An easy-to-synthesize ruthenium phthalimide complex (tan-colored carbon atoms in the picture) was designed to bind within the active site of the p21-activated kinase 1 in a novel fashion that differs from that of the previously established staurosporine-inspired metallopyridocarbazoles (gray-colored carbon atoms).

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