SEARCH

SEARCH BY CITATION

Keywords:

  • cyanides;
  • formamide;
  • nucleobases;
  • prebiotic chemistry;
  • purines
Thumbnail image of graphical abstract

Form(am)idable beginning: Mechanistic pathways from formamide to purine and adenine have been proposed (see scheme, purine (R=H, X=H), adenine (R=CN, X=NH2, R′=CONH2). Parallels between these plausible prebiotic syntheses and purine-ring biosynthesis may allude to the origins of the metabolic route.