This work was jointly supported by NSF and the NASA Astrobiology Program under the NSF Center for Chemical Evolution, CHE1004570.
A Unified Mechanism for Abiotic Adenine and Purine Synthesis in Formamide†
Article first published online: 5 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 21, pages 5134–5137, May 21, 2012
How to Cite
Hudson, J. S., Eberle, J. F., Vachhani, R. H., Rogers, L. C., Wade, J. H., Krishnamurthy, R. and Springsteen, G. (2012), A Unified Mechanism for Abiotic Adenine and Purine Synthesis in Formamide . Angew. Chem. Int. Ed., 51: 5134–5137. doi: 10.1002/anie.201108907
- Issue published online: 15 MAY 2012
- Article first published online: 5 APR 2012
- Manuscript Revised: 9 FEB 2012
- Manuscript Received: 17 DEC 2011
- NASA Astrobiology Program. Grant Number: CHE1004570
- prebiotic chemistry;
Form(am)idable beginning: Mechanistic pathways from formamide to purine and adenine have been proposed (see scheme, purine (R=H, X=H), adenine (R=CN, X=NH2, R′=CONH2). Parallels between these plausible prebiotic syntheses and purine-ring biosynthesis may allude to the origins of the metabolic route.