We thank Prof. Dr. D. C. Rees and Dr. Nathan Dalleska of Caltech (Pasadena) for help with the GC-MS analysis. This work was supported by Herman Frasch Foundation grant 617-HF07 (M.W.R.) and NIH grant GM-67626 (M.W.R.).
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Communication
ATP-Independent Formation of Hydrocarbons Catalyzed by Isolated Nitrogenase Cofactors†
Article first published online: 17 JAN 2012
DOI: 10.1002/anie.201108916
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Lee, C. C., Hu, Y. and Ribbe, M. W. (2012), ATP-Independent Formation of Hydrocarbons Catalyzed by Isolated Nitrogenase Cofactors. Angew. Chem. Int. Ed., 51: 1947–1949. doi: 10.1002/anie.201108916
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Publication History
- Issue published online: 14 FEB 2012
- Article first published online: 17 JAN 2012
- Manuscript Revised: 3 JAN 2012
- Manuscript Received: 18 DEC 2011
Funded by
- Herman Frasch Foundation. Grant Number: 617-HF07
- NIH. Grant Number: GM-67626
Keywords:
- carbon monoxide;
- cofactors;
- enzymes;
- hydrocarbons;
- nitrogenases
Reduce to produce: Molybdenum- and vanadium-nitrogenase cofactors have been isolated and shown to reduce carbon monoxide and cyanide ions to a mixture of alkanes and alkenes in the presence of a strong reductant, europium(II) diethylenetriaminepentaacetate (see scheme). Various hydrocarbons of up to seven carbon atoms in length are detected as products in these ATP-free reactions.