Inside Back Cover

Inside Back Cover: Fine-tuning the π–π Aromatic Interactions in Peptides: Somatostatin Analogues Containing Mesityl Alanine (Angew. Chem. Int. Ed. 8/2012)

  1. Pablo Martín-Gago1,
  2. Dr. Marc Gomez-Caminals4,
  3. Dr. Rosario Ramón1,2,
  4. Prof. Xavier Verdaguer1,2,
  5. Pau Martin-Malpartida1,
  6. Eric Aragón1,
  7. Dr. Jimena Fernández-Carneado4,
  8. Dr. Berta Ponsati4,
  9. Prof. Pilar López-Ruiz5,
  10. Maria Alicia Cortes5,
  11. Prof. Begoña Colás5,
  12. Prof. Maria J. Macias1,3,*,
  13. Prof. Antoni Riera1,2,*

Article first published online: 5 JAN 2012

DOI: 10.1002/anie.201108928

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 8, page 1977, February 20, 2012

Additional Information

How to Cite

Martín-Gago, P., Gomez-Caminals, M., Ramón, R., Verdaguer, X., Martin-Malpartida, P., Aragón, E., Fernández-Carneado, J., Ponsati, B., López-Ruiz, P., Cortes, M. A., Colás, B., Macias, M. J. and Riera, A. (2012), Inside Back Cover: Fine-tuning the π–π Aromatic Interactions in Peptides: Somatostatin Analogues Containing Mesityl Alanine (Angew. Chem. Int. Ed. 8/2012). Angew. Chem. Int. Ed., 51: 1977. doi: 10.1002/anie.201108928

Author Information

  1. 1

    Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac, 10, 08028 Barcelona (Spain)

  2. 2

    Departament de Química Orgànica, Universitat de Barcelona, Martí i Franqués, 1–11, 08028 Barcelona (Spain)

  3. 3

    Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluis Companys 23, Barcelona (Spain)

  4. 4

    BCN Peptides, S.A. (Lipotec Group) Barcelona (Spain)

  5. 5

    Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá de Henares, Facultad de Medicina, Madrid (Spain)

*Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac, 10, 08028 Barcelona (Spain)

Publication History

  1. Issue published online: 14 FEB 2012
  2. Article first published online: 5 JAN 2012

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Keywords:

  • conformation analysis;
  • NMR spectroscopy;
  • noncovalent interactions;
  • peptides;
  • drug design
Thumbnail image of graphical abstract

The π–π aromatic interactions between amino acids 6, 7, and 11 in the natural hormone somatostatin are crucial for conformational stability. In their Communication on page 1820 ff., M. J. Macias, A. Riera, and co-workers describe that peptidic analogues obtained by replacing each phenylalanine with mesitylalanine are conformationally more rigid than the parent hormone. This strategy has yielded the first 3D structures of 14-amino-acid somatostatin analogues.

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