Financial support for this research was provided by the MICINN (project number CTQ2009-08328 and Consolider Ingenio-2010 CSD2007-00006) and by a Bruker-Lilly agreement. We also thank the Servei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, for allocating instrument time to this project.
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Communication
A Definitive NMR Solution for a Simple and Accurate Measurement of the Magnitude and the Sign of Small Heteronuclear Coupling Constants on Protonated and Non-Protonated Carbon Atoms†
Article first published online: 12 MAR 2012
DOI: 10.1002/anie.201108959
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Saurí, J., Espinosa, J. F. and Parella, T. (2012), A Definitive NMR Solution for a Simple and Accurate Measurement of the Magnitude and the Sign of Small Heteronuclear Coupling Constants on Protonated and Non-Protonated Carbon Atoms. Angew. Chem. Int. Ed., 51: 3919–3922. doi: 10.1002/anie.201108959
- †
Publication History
- Issue published online: 11 APR 2012
- Article first published online: 12 MAR 2012
- Manuscript Revised: 6 FEB 2012
- Manuscript Received: 19 DEC 2011
Funded by
- MICINN. Grant Numbers: CTQ2009-08328, CSD2007-00006
Keywords:
- coupling constants;
- NMR spectroscopy;
- structure elucidation
Simply successful: A proton-selective HSQMBC-TOCSY experiment can be used to measure small proton–carbon (nJCH; n>1) coupling constants on both protonated and non-protonated carbon atoms (see spectrum). The method combines in a single pulse scheme all the benefits of the widely used HSQMBC and HSQC-TOCSY experiments. The magnitude and the sign of nJCH can be determined simply with excellent accuracy.