Homogeneous Biogenic Paramagnetic Nanoparticle Synthesis Based on a Microfluidic Droplet Generator

Authors

  • Jae Hwan Jung,

    1. Department of Chemical and Biomolecular Engineering (BK21 program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701 (Republic of Korea) http://nanobiomems.kaist.ac.kr
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Dr. Tae Jung Park,

    1. Department of Chemical and Biomolecular Engineering (BK21 program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701 (Republic of Korea) http://nanobiomems.kaist.ac.kr
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Prof. Sang Yup Lee,

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering (BK21 program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701 (Republic of Korea) http://nanobiomems.kaist.ac.kr
    • Department of Chemical and Biomolecular Engineering (BK21 program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701 (Republic of Korea) http://nanobiomems.kaist.ac.kr
    Search for more papers by this author
  • Prof. Tae Seok Seo

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering (BK21 program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701 (Republic of Korea) http://nanobiomems.kaist.ac.kr
    • Department of Chemical and Biomolecular Engineering (BK21 program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701 (Republic of Korea) http://nanobiomems.kaist.ac.kr
    Search for more papers by this author

  • This work was supported by the R&D Program of MKE/KEIT [10035638] and by the Advanced Biomass R&D Center (ABC) and Intelligent Synthetic Biology Center of Global Frontier Project funded by the Ministry of Education, Science and Technology (2011-0031357, 2011-0031963).

Abstract

original image

All under control: A microfluidic droplet generator uniformly encapsulates an equivalent number of engineered E. coli cells and the same Fe and Mn metal ion concentrations in identically sized droplets. The synthesized biogenic FeMn paramagnetic nanoparticles inside the cells are eco-friendly and cost-effective.

Ancillary