Chemical Synthesis of an Erythropoietin Glycoform Containing a Complex-type Disialyloligosaccharide


  • Financial support from the Japan Society for the Promotion of Science (No. A 23245037) is acknowledged.


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New and improved: New reaction conditions for tert-Boc-based solid-phase peptide synthesis make acid-labile sialyloligosaccharyl peptide α-thioesters accessible. To demonstrate this, a sialyloligosaccharyl-erythropoietin glycoform (see picture) with 166 amino acid residues was synthesized.