Cinchona-based Primary Amine Catalysis in the Asymmetric Functionalization of Carbonyl Compounds

Authors

  • Prof. Dr. Paolo Melchiorre

    Corresponding author
    1. ICREA—Institució Catalana de Recerca i Estudis Avançats, Passeig Lluís Companys 23, 08010 Barcelona (Spain)
    2. ICIQ—Institute of Chemical Research of Catalonia, Avenida Països Catalans 16, 43007 Tarragona (Spain) http://www.iciq.es/portal/862/default.aspx
    • ICREA—Institució Catalana de Recerca i Estudis Avançats, Passeig Lluís Companys 23, 08010 Barcelona (Spain)
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Abstract

Asymmetric aminocatalysis exploits the potential of chiral primary and secondary amines to catalyze asymmetric reactions. It has greatly simplified the functionalization of carbonyl compounds while ensuring high enantioselectivity. Recent advances in cinchona-based primary amine catalysis have provided new synthetic opportunities and conceptual perspectives for successfully attacking major challenges in carbonyl compound chemistry, which traditional approaches have not been able to address. This Review outlines the historical context for the development of this catalyst class while charting the landmark discoveries and applications that have further expanded the synthetic potential of aminocatalysis.

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