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  • Open Access

Towards a Structural Basis for the Relationship Between Blood Group and the Severity of El Tor Cholera

Authors

  • Dr. Pintu K. Mandal,

    1. School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT (UK)
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  • Thomas R. Branson,

    1. School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT (UK)
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  • Dr. Edward D. Hayes,

    1. School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT (UK)
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  • James F. Ross,

    1. School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT (UK)
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  • Dr. Jose A. Gavín,

    1. Instituto Universitario de Bio-Organica “Antonio Gonzalez”, Av. Astrofísico Francisco Sanchez 2, 38206, La Laguna, Santa Cruz de Tenerife, Canary Islands (Spain)
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  • Dr. Antonio H. Daranas,

    1. Instituto Universitario de Bio-Organica “Antonio Gonzalez”, Av. Astrofísico Francisco Sanchez 2, 38206, La Laguna, Santa Cruz de Tenerife, Canary Islands (Spain)
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  • Dr. W. Bruce Turnbull

    Corresponding author
    1. School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT (UK)
    • School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT (UK)
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  • We thank Prof. T. R. Hirst for providing clones for expressing El Tor CTB and LTBh. This work was supported by the Royal Society through a Newton International Fellowship (PKM) and a Royal Society University Research Fellowship (WBT). We also thank EPSRC (EP/G043302/1), MICIIN (CTQ2008-06754-C04-01), the Wellcome Trust (089308/Z/09/Z), and AstraZeneca for financial support.

Abstract

original image

It has long been known that people with blood group O are more severely affected by El Tor cholera than those with blood groups A or B. Microcalorimetry and NMR spectroscopy are used to evaluate the ability of the B-subunits of cholera toxin and E. coli heat-labile toxin to bind to selected blood group oligosaccharides.

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