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Keywords:

  • antitumor agents;
  • multicomponent reactions;
  • natural products;
  • spiro compounds;
  • total synthesis
Thumbnail image of graphical abstract

Supply chain: The polycyclic core of (−)-berkelic acid (1) was constructed in just one step from very simple starting materials. The total synthesis of 1 involves a seven-step linear sequence. Protection/deprotection steps were avoided and all but the last step were performed on a gram scale. This synthesis could solve the supply problem associated with the exhaustion of the natural source.