Inside Back Cover: Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols (Angew. Chem. Int. Ed. 12/2012)

Authors

  • Dr. Yuanpei Li,

    1. Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California, Davis, 2700 Stockton Blvd., Sacramento, CA 95817 (USA)
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    • These authors contributed equally to this work.

  • Dr. Wenwu Xiao,

    1. Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California, Davis, 2700 Stockton Blvd., Sacramento, CA 95817 (USA)
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    • These authors contributed equally to this work.

  • Dr. Kai Xiao,

    1. Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California, Davis, 2700 Stockton Blvd., Sacramento, CA 95817 (USA)
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  • Dr. Lorenzo Berti,

    1. Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California, Davis, 2700 Stockton Blvd., Sacramento, CA 95817 (USA)
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  • Prof. Juntao Luo,

    Corresponding author
    1. Department of Pharmacology, SUNY Upstate Cancer Research Institute, SUNY Upstate Medical University, Syracuse, NY 13210 (USA)
    • Department of Pharmacology, SUNY Upstate Cancer Research Institute, SUNY Upstate Medical University, Syracuse, NY 13210 (USA)
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  • Harry P. Tseng,

    1. Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California, Davis, 2700 Stockton Blvd., Sacramento, CA 95817 (USA)
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  • Gabriel Fung,

    1. Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California, Davis, 2700 Stockton Blvd., Sacramento, CA 95817 (USA)
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  • Prof. Kit S. Lam

    Corresponding author
    1. Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California, Davis, 2700 Stockton Blvd., Sacramento, CA 95817 (USA)
    • Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California, Davis, 2700 Stockton Blvd., Sacramento, CA 95817 (USA)
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Abstract

original image

A cross-linked micellar nanocarrier system for on-demand drug delivery is described by J. Luo, K. S. Lam, and co-workers in their Communication on page 2864 ff. The reversible catechol boronate cross-link increases the stability of the nanocarriers against severe conditions in the blood stream. After the ball-like nanocarriers reach the tumor target, the cross-links are cleaved by the acidic tumor environment or by exogenous cis-diols (e.g. mannitol), causing the ball to burst and releasing the drug.

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