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Keywords:

  • α-methylene-γ-lactones;
  • carboesterification;
  • palladium;
  • reductive elimination;
  • synthetic methods
Thumbnail image of graphical abstract

Three in one: A highly efficient and mild PdII-catalyzed carboesterification of alkenes with carboxylic alkyne derivatives proceeds through a domino-type alkyne–alkene coupling/C[BOND]O-bond formation (see scheme). The stereoselectivity is controlled by the choice of substrates and temperature. The reaction provides a convenient method for the construction of naturally occurring biologically active compounds with α-methylene-γ-lactone skeletons.