Total Syntheses of All the Amathaspiramides


  • Financial support for this work was provided by Grants-in-Aid (21790009 and 20002004) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.


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Six in one blow: Total syntheses of all the amathaspiramide alkaloids have been accomplished. Rapid construction of the diazaspiro[3.3]nonane core combined with regio- and diastereoselective reduction of the cyclic imide moiety with DIBAL established the route to the common structural motif. The late-stage reduction of the lactam to an imine functionality mediated by Schwartz's reagent was the key to the streamlined syntheses.