These authors contributed equally to this work.
2-Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms†
Article first published online: 5 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 21, pages 5226–5229, May 21, 2012
How to Cite
Frei, R., Breitbach, A. S. and Blackwell, H. E. (2012), 2-Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms . Angew. Chem. Int. Ed., 51: 5226–5229. doi: 10.1002/anie.201109258
Financial support for this work was provided by the NIH (AI063326), ONR (N00014-07-1-0255), Greater Milwaukee Foundation Shaw Scientist Program, Burroughs Welcome Fund, and Johnson & Johnson. A.S.B. was funded in part by an NIH Chemistry-Biology Interface Training Grant (NIGMS T32 GM008505). We gratefully acknowledge Prof. Barbara Iglewski and Prof. Søren Molin for donations of bacterial strains, and J. P. Gerdt for technical assistance.
- Issue published online: 15 MAY 2012
- Article first published online: 5 APR 2012
- Manuscript Received: 30 DEC 2011
- NIH. Grant Number: AI063326
- ONR. Grant Number: N00014-07-1-0255
- Greater Milwaukee Foundation Shaw Scientist Program
- Burroughs Welcome Fund
- Johnson & Johnson
- drug discovery;
- nitrogen heterocycles;
- synthetic methods
Bacterial biofilms are exceptionally difficult to clear using traditional antibiotics and constitute a significant health threat. 2-Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known.