2-Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms


  • Financial support for this work was provided by the NIH (AI063326), ONR (N00014-07-1-0255), Greater Milwaukee Foundation Shaw Scientist Program, Burroughs Welcome Fund, and Johnson & Johnson. A.S.B. was funded in part by an NIH Chemistry-Biology Interface Training Grant (NIGMS T32 GM008505). We gratefully acknowledge Prof. Barbara Iglewski and Prof. Søren Molin for donations of bacterial strains, and J. P. Gerdt for technical assistance.


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Bacterial biofilms are exceptionally difficult to clear using traditional antibiotics and constitute a significant health threat. 2-Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known.