P.S. is grateful to the Fonds der Chemischen Industrie for a Kekulé Fellowship. We thank S. Strych, D. T. Hog, D. Woodmansee, and V. Erdmann for their helpful discussions. This work was funded by SFB 870 and the ERC (grant no. 268795).
A Photochromic Agonist of AMPA Receptors†
Article first published online: 19 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 23, pages 5748–5751, June 4, 2012
How to Cite
Stawski, P., Sumser, M. and Trauner, D. (2012), A Photochromic Agonist of AMPA Receptors. Angew. Chem. Int. Ed., 51: 5748–5751. doi: 10.1002/anie.201109265
- Issue published online: 30 MAY 2012
- Article first published online: 19 APR 2012
- Manuscript Received: 31 DEC 2012
- Fonds der Chemischen Industrie
- bioorganic chemistry;
- diazo compounds;
- optochemical genetics;
Light switch: A photochromic agonist ATA-3 (see scheme) of AMPA receptors, arguably the most important class of ionotropic glutamate receptors, is shown to be subtype selective, activates the AMPA receptor GluA2 in the dark, and is quickly turned off when irradiated with blue–green light. It can be used to effectively control neuronal activity in the mammalian brain.