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Keywords:

  • convergent coupling;
  • deoxypropionates;
  • metallacycles;
  • polyketides;
  • titanium;
  • total synthesis
Thumbnail image of graphical abstract

Metallacycle-mediated allylic alcohol–alkyne reductive cross-coupling is described as a convergent solution to the synthesis of deoxypropionates. This approach offers superior step-economy in comparison to available strategies based on multistep iterative chain elongation. The technique is demonstrated in a concise synthesis of the C1–C11 subunit of borrelidin, and a total synthesis of (−)-vittatalactone.