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Keywords:

  • bioinformatics;
  • biosynthesis;
  • polyketides;
  • stereochemistry;
  • structure elucidation
Thumbnail image of graphical abstract

Decoded before decay: Cryptic and highly unstable polyketide metabolites, thailandamides A and B, were isolated from Burkholderia thailandensis, and their absolute configurations fully elucidated using a combination of chemical degradation, bioinformatics, NMR spectroscopy, precursor-directed biosynthesis, and analysis of pathway intermediates (see scheme).