We thank A. Perner, H. Heinecke, and F. Rhein for MS and NMR measurements. This research was financially supported by the Pakt für Wissenschaft und Innovation.
Assembly and Absolute Configuration of Short-Lived Polyketides from Burkholderia thailandensis†
Article first published online: 19 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 22, pages 5470–5474, May 29, 2012
How to Cite
Ishida, K., Lincke, T. and Hertweck, C. (2012), Assembly and Absolute Configuration of Short-Lived Polyketides from Burkholderia thailandensis . Angew. Chem. Int. Ed., 51: 5470–5474. doi: 10.1002/anie.201200067
- Issue published online: 23 MAY 2012
- Article first published online: 19 APR 2012
- Manuscript Revised: 5 MAR 2012
- Manuscript Received: 4 JAN 2012
- Pakt für Wissenschaft und Innovation
- structure elucidation
Decoded before decay: Cryptic and highly unstable polyketide metabolites, thailandamides A and B, were isolated from Burkholderia thailandensis, and their absolute configurations fully elucidated using a combination of chemical degradation, bioinformatics, NMR spectroscopy, precursor-directed biosynthesis, and analysis of pathway intermediates (see scheme).