Financial support from the 973 Program (2011CB932404 and 2011CBA00501), the NSFC (20821061 and 20925102), the Key Project from CAS and NSF of Fujian Province (2009HZ0005) is greatly appreciated.
A General Pd-Catalyzed Decarboxylative Cross-Coupling Reaction between Aryl Carboxylic Acids: Synthesis of Biaryl Compounds†
Article first published online: 11 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 24, pages 5945–5949, June 11, 2012
How to Cite
Hu, P., Shang, Y. and Su, W. (2012), A General Pd-Catalyzed Decarboxylative Cross-Coupling Reaction between Aryl Carboxylic Acids: Synthesis of Biaryl Compounds. Angew. Chem. Int. Ed., 51: 5945–5949. doi: 10.1002/anie.201200153
- Issue published online: 5 JUN 2012
- Article first published online: 11 APR 2012
- Manuscript Received: 7 JAN 2012
- 973 Program. Grant Numbers: 2011CB932404, 2011CBA00501
- NSFC. Grant Numbers: 20821061, 20925102
- Key Project from CAS and NSF of Fujian Province. Grant Number: 2009HZ0005
- carboxylic acids;
Acid to acid: A general method has been developed for the synthesis of biaryl compounds through a decarboxylative cross-coupling reaction between two different (hetero)aryl carboxylic acids (see scheme). The use of a PdII/PCy3 catalyst enables the cross-coupling reaction of electronically different or electronically similar aryl carboxylic acids. This method is compatible with substrates having nitro, cyano, fluoro, chloro, bromo, trifluoromethyl, and methoxy substituents.