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Keywords:

  • biaryls;
  • carboxylic acids;
  • cross-coupling;
  • decarboxylation;
  • heterocycles
Thumbnail image of graphical abstract

Acid to acid: A general method has been developed for the synthesis of biaryl compounds through a decarboxylative cross-coupling reaction between two different (hetero)aryl carboxylic acids (see scheme). The use of a PdII/PCy3 catalyst enables the cross-coupling reaction of electronically different or electronically similar aryl carboxylic acids. This method is compatible with substrates having nitro, cyano, fluoro, chloro, bromo, trifluoromethyl, and methoxy substituents.