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Keywords:

  • asymmetric catalysis;
  • N-heterocyclic carbenes;
  • oxindoles;
  • palladium;
  • synthetic methods
Thumbnail image of graphical abstract

Modus operandi: Catalytic access to the title compounds through a new asymmetric α-arylation protocol is reported (see scheme). These products are formed in good yields and excellent enantioselectivities by using a new and easily synthesized chiral N-heterocyclic carbene (NHC) ligand. Advanced DFT calculations reveal the properties of the NHC ligand and the mode of operation of the catalyst.