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Keywords:

  • biosynthesis;
  • myxobacteria;
  • natural products;
  • Sorangium cellulosum;
  • total synthesis
Thumbnail image of graphical abstract

Genetic analysis of biosynthetic gene clusters is becoming an accepted tool to predict the stereochemical outcome of a biosynthesis. However, in the case of pellasoren, one chiral center was not predicted correctly. The absolute configuration was verified by total synthesis, which also demonstrated that stereoselective protonations can be successfully applied to natural products synthesis.