These authors contributed equally to this work.
Pellasoren: Structure Elucidation, Biosynthesis, and Total Synthesis of a Cytotoxic Secondary Metabolite from Sorangium cellulosum†
Article first published online: 5 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 21, pages 5239–5243, May 21, 2012
How to Cite
Jahns, C., Hoffmann, T., Müller, S., Gerth, K., Washausen, P., Höfle, G., Reichenbach, H., Kalesse, M. and Müller, R. (2012), Pellasoren: Structure Elucidation, Biosynthesis, and Total Synthesis of a Cytotoxic Secondary Metabolite from Sorangium cellulosum . Angew. Chem. Int. Ed., 51: 5239–5243. doi: 10.1002/anie.201200327
We thank Daniel Krug for proofreading the manuscript, Jennifer Herrmann for performing the bioactivity assays, and Susanne Schneiker-Bekel for genome sequencing. Research in R.M’s laboratory was funded by the Bundesministerium für Bildung und Forschung and the Deutsche Forschungsgemeinschaft.
- Issue published online: 15 MAY 2012
- Article first published online: 5 APR 2012
- Manuscript Revised: 16 FEB 2012
- Manuscript Received: 12 JAN 2012
- Bundesministerium für Bildung und Forschung
- Deutsche Forschungsgemeinschaft
- natural products;
- Sorangium cellulosum;
- total synthesis
Genetic analysis of biosynthetic gene clusters is becoming an accepted tool to predict the stereochemical outcome of a biosynthesis. However, in the case of pellasoren, one chiral center was not predicted correctly. The absolute configuration was verified by total synthesis, which also demonstrated that stereoselective protonations can be successfully applied to natural products synthesis.