We acknowledge LabRMN at FCT/UNL and Rede Nacional de RMN for access to the facilities. Rede Nacional is supported with funds from FCT-Lisbon, Projecto de Re-equipamento Científico, Portugal. We thank the financial support from Fundação para a Ciência e a Tecnologia (FC&T) through projects PTDC/CTM/099452/2008, PTDC/EME-TME/103375/2008 and MIT-Pt/Bs-CTRM/0051/2008, and PhD grants SFRH/BD/66858/2009 (R.B.R.) and SFRH/BD/80648/2011 (P.I.M.). V.D.B.B. is supported by the MIT-Portugal Program (Bioengineering Systems Focus Area).
Biocompatible Polyurea Dendrimers with pH-Dependent Fluorescence†
Article first published online: 5 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 21, pages 5162–5165, May 21, 2012
How to Cite
Restani, R. B., Morgado, P. I., Ribeiro, M. P., Correia, I. J., Aguiar-Ricardo, A. and Bonifácio, V. D. B. (2012), Biocompatible Polyurea Dendrimers with pH-Dependent Fluorescence . Angew. Chem. Int. Ed., 51: 5162–5165. doi: 10.1002/anie.201200362
- Issue published online: 15 MAY 2012
- Article first published online: 5 APR 2012
- Manuscript Received: 13 JAN 2012
- Fundação para a Ciência e a Tecnologia (FC&T). Grant Numbers: PTDC/CTM/099452/2008, PTDC/EME-TME/103375/2008, MIT-Pt/Bs-CTRM/0051/2008
- supercritical carbon dioxide
Blue: Biocompatible and biodegradable water-soluble dendrimers comprising ureas within the interior and amino groups on the periphery were synthesized in supercritical carbon dioxide (dendrimer of generation 1 shown in picture). This novel class of dendrimers shows a pH-dependent intrinsic blue fluorescence at very low concentrations, which makes them potential polymeric fluorescent cell markers.