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Biocompatible Polyurea Dendrimers with pH-Dependent Fluorescence


  • We acknowledge LabRMN at FCT/UNL and Rede Nacional de RMN for access to the facilities. Rede Nacional is supported with funds from FCT-Lisbon, Projecto de Re-equipamento Científico, Portugal. We thank the financial support from Fundação para a Ciência e a Tecnologia (FC&T) through projects PTDC/CTM/099452/2008, PTDC/EME-TME/103375/2008 and MIT-Pt/Bs-CTRM/0051/2008, and PhD grants SFRH/BD/66858/2009 (R.B.R.) and SFRH/BD/80648/2011 (P.I.M.). V.D.B.B. is supported by the MIT-Portugal Program (Bioengineering Systems Focus Area).


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Blue: Biocompatible and biodegradable water-soluble dendrimers comprising ureas within the interior and amino groups on the periphery were synthesized in supercritical carbon dioxide (dendrimer of generation 1 shown in picture). This novel class of dendrimers shows a pH-dependent intrinsic blue fluorescence at very low concentrations, which makes them potential polymeric fluorescent cell markers.

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