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Catalytic, Atom-Economical Radical Arylation of Epoxides


  • We are grateful to support from the National Science Foundation of the USA (CHE 1123815) and the Deutsche Forschungsgemeinschaft (SFB 813 “Chemistry at Spin Centers”). We thank Todd A. Maisano for initial contributions to rate studies.


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A slow electron waltz: Catalysis in single-electron steps with radicals as intermediates is essential for an atom-economical arylation of epoxides with a proton-coupled electron transfer as a key step. Stabilization of the catalyst is essential for low catalyst loading, as demonstrated by reaction-progress kinetic analysis, cyclic voltammetry, and calculations.

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