Dynamic 3D Patterning of Biochemical Cues by using Photoinduced Bioorthogonal Reactions


  • We would like to acknowledge financial support for our research from the US NSF CHE-0748690, and the U.S. Army Research Office under contract/grant number DoD-W911NF-09-1-0236. Q.W. is grateful for the Robert L. Sumwalt Prof. endowment at USC.


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Click, click, and lights on: A new generation of biomaterials for use as cell-supporting scaffolds includes added features to mimic the natural temporal and spatial control of bioactive ligands. The reported system uses one cycle to add and remove biorelevant ligands, which is a step towards representing the dynamic progression of natural organ and tissue development.